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Updated: May 27, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Emerging Role of Macrophage-Fibroblast Interactions in Cardiac Homeostasis and Remodeling

Xu-Zhe Zhang1,2,3, Qin-Lin Li1,2,3, Ting-Ting Tang1,2,3

  • 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

JACC. Basic to Translational Science
|February 17, 2025
PubMed

Insights

Cardiac macrophages and fibroblasts are key to heart health and repair. Understanding their complex interactions is vital for treating cardiac remodeling and improving heart function.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Cell Biology

Background:

  • Macrophages and fibroblasts are critical noncardiomyocyte cells in the heart.
  • These cells are involved in maintaining cardiac homeostasis and responding to injury.
  • Their plasticity and heterogeneity influence cardiac remodeling, both adaptive and adverse.

Purpose of the Study:

  • To review the molecular mechanisms of macrophage-fibroblast interactions in the heart.
  • To highlight recent research advancements in this field.
  • To provide a translational perspective on these interactions.

Main Methods:

  • Comprehensive literature review of recent studies.
  • Analysis of molecular signaling pathways involved in cell-cell communication.
  • Evaluation of translational potential for therapeutic strategies.

Main Results:

  • Macrophage-fibroblast interactions are complex and context-dependent.
  • These interactions significantly influence cardiac repair and remodeling processes.
  • Specific molecular mediators and signaling pathways have been identified.

Conclusions:

  • Understanding macrophage-fibroblast crosstalk is essential for cardiac health.
  • Targeting these interactions holds therapeutic potential for cardiac diseases.
  • Further research is needed to translate these findings into clinical practice.

Keywords:
cardiac homeostasiscardiac remodelingfibroblastintercellular interactionmacrophage

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