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Personal access to sequence databases on personal computers.

P E Doggett, F R Blattner

    Nucleic Acids Research
    |January 10, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    A new software package allows personal computers to access biological sequence databases. This cost-effective solution enables keyword and pattern matching for nucleic acid and protein sequence analysis.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Molecular Biology

    Background:

    • Accessing large biological sequence databases traditionally required mainframe computers.
    • Advancements in personal computer hardware, particularly hard disk storage, have increased their capabilities.

    Purpose of the Study:

    • To develop a software package for accessing nucleic acid and protein sequence databases on personal computers.
    • To enable sophisticated sequence analysis directly on a stand-alone platform.

    Main Methods:

    • Developed a software package integrating keyword searching of annotation fields.
    • Implemented pattern matching algorithms for biological sequence analysis.
    • Utilized stand-alone IBM personal computers for database access and analysis.

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    Main Results:

    • The software facilitates identification of sequences with specific functional sites (e.g., promoters, kink sites).
    • Enables similarity searches against query sequences.
    • Allows identification of specific protein patterns, such as hydrophobic regions.

    Conclusions:

    • Personal computers offer a cost-effective alternative to mainframes for sequence database processing.
    • The developed software enhances accessibility and analytical power for biological sequence data on personal computers.