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Updated: Feb 7, 2026

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
Published on: January 12, 2015
Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear
Li-Zhi Cheng1,2, Fu-Ying Qin3,4, Xiao-Chi Ma5
1School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. 13424039397@163.com.
Abstract:
Seven compounds, including two pairs of new meroterpenoids, (+)- and (-)-gancochlearol C (1), (+)- and (-)-cochlearoid Q (3), and a new meroterpenoid gancochlearol D (2), together with four known meroterpenoids were isolated from the aqueous EtOH extract of the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data. The isolated compounds were evaluated for their cytotoxic activity against three human lung cancer cells (H1975, PC9, A549) and N-acetyltransferase inhibitory property. The results show that (+)-gancochlearol C could inhibit N-acetyltransferase with an IC50 value of 5.29 μM. In addition, ganomycin F was found to show moderate activity against the H1975 human lung cancer cell line, with an IC50 value of 19.47 μM.
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