Related Experiment Video

Updated: Feb 7, 2026

Ammonia Fiber Expansion AFEX Pretreatment of Lignocellulosic Biomass
09:30

Ammonia Fiber Expansion AFEX Pretreatment of Lignocellulosic Biomass

Published on: April 18, 2020

14.4K

[Apatinib as Salvage Therapy for Heavily Pretreated SCLC]

Fangfang Li1, Haitao Tao2

  • 1Department of State Guest, Institute of Health Management, the Chinese PLA General Hospital, Beijing 100853, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|July 25, 2018
PubMed

Insights

Apatinib, an anti-angiogenic drug, showed partial response in advanced small cell lung cancer (SCLC) after chemotherapy failure. This targeted therapy offers potential for difficult-to-treat SCLC cases.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Small cell lung cancer (SCLC) is highly malignant with limited treatment options post-chemotherapy and radiotherapy failure.
  • Antiangiogenic therapy, targeting tumor vascularization, presents a potential strategy for advanced SCLC.

Observation:

  • A patient with advanced SCLC and Gilbert syndrome received apatinib after four prior chemotherapy lines.
  • Apatinib, a VEGFR-2 inhibitor, was administered as a salvage treatment option.

Findings:

  • The patient achieved a partial response (RECIST 1.1) after one month of apatinib treatment.
  • Progression-free survival (PFS) was 5 months.
  • Apatinib was generally well-tolerated, with the main adverse event being recurrent grade 3 hyperbilirubinemia due to Gilbert syndrome.

Implications:

  • Apatinib demonstrates potential efficacy as a salvage therapy for advanced SCLC, even in patients with underlying bilirubin metabolism disorders.
  • Further clinical investigation of apatinib for advanced SCLC is warranted to explore its therapeutic role.
Keywords:
AngiogenesisApatinibGilbert syndromeSmall cell lung cancer

More Related Videos

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids10:42

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

19.0K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

652

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
450
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
728
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
302
Cognitive Therapy01:25

Cognitive Therapy

Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.1K