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Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
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Adrenocortical oncocytic neoplasm: A systematic review
John J Kanitra1, John C Hardaway2, Tahereh Soleimani3
1Department of Surgery, St. John Hospital and Medical Center, Detroit, MI.
Surgery
|July 25, 2018
Summary
Adrenocortical oncocytic neoplasms are often malignant or have malignant potential, contrary to prior beliefs. The Lin-Weiss-Bisceglia criteria aid in identifying patients needing closer surveillance for better prognosis.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Adrenocortical oncocytic neoplasms are rare, typically considered benign and nonfunctional.
- Existing literature is primarily based on single-case reports, necessitating a comprehensive review.
Observation:
- A systematic review analyzed 140 adrenocortical oncocytic neoplasms from 84 citations.
- The majority occurred in females (66%), on the left side (64%), and were nonfunctional (66%).
- Median tumor size was 80 mm, with a mean age at diagnosis of 44 years.
Findings:
- 35% were benign, 41% borderline, and 24% malignant.
- Malignant tumors were more common in males (36% vs. 18%).
- 5-year survival rates were 100% for benign, 88% for borderline, and 47% for malignant neoplasms.
- Synaptophysin positivity and vimentin negativity correlated with benignancy.
Implications:
- Contrary to previous literature, 65% of these neoplasms showed malignancy or malignant potential.
- The Lin-Weiss-Bisceglia criteria are crucial for identifying high-risk patients.
- Prognosis is significantly influenced by the Lin-Weiss-Bisceglia classification, guiding surveillance strategies.
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