Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.4K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.4K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.9K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.9K
Reversible and Irreversible Processes01:14

Reversible and Irreversible Processes

5.8K
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
5.8K
Diode: Reverse bias01:14

Diode: Reverse bias

2.0K
A diode is reverse-biased when the positive terminal of an external voltage source is connected to the n-type material and the negative terminal to the p-type material. This configuration opposes the natural direction of current flow through the diode, effectively increasing the width of the depletion region and the barrier potential. The reverse bias condition produces a minimal leakage current, primarily due to minority charge carriers. This leakage becomes significant when the reverse...
2.0K
Modeling of Diode Reverse Characteristics01:14

Modeling of Diode Reverse Characteristics

632
In electronic circuits, reverse-biased diode configurations are critical for regulating voltage levels. Zener diodes exploit the reverse breakdown phenomenon and exhibit a controlled breakdown at a specific Zener voltage (VZ). They are designed to maintain a constant voltage across their terminals and are commonly used for voltage regulation in circuits.
When a reverse voltage applied to a Zener diode exceeds its breakdown voltage, the diode enters the breakdown region. At this point, the...
632
Entropy Change in Reversible Processes01:10

Entropy Change in Reversible Processes

3.2K
In the Carnot engine, which achieves the maximum efficiency between two reservoirs of fixed temperatures, the total change in entropy is zero. The observation can be generalized by considering any reversible cyclic process consisting of many Carnot cycles. Thus, it can be stated that the total entropy change of any ideal reversible cycle is zero.
The statement can be further generalized to prove that entropy is a state function. Take a cyclic process between any two points on a p-V diagram.
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparing Emergency Medicine Residents for the Certifying Exam: A Pilot Study of a Longitudinal Simulation-Based Assessment Program.

AEM education and training·2026
Same author

Implementation Strategy for an Education Value Unit System in Emergency Medicine at The Ohio State University.

Journal of the American College of Emergency Physicians open·2025
Same author

Validation of a Simulation-Based Resuscitation Curriculum for Maternal Cardiac Arrest.

Obstetrics and gynecology·2023
Same author

Interrater agreement of the HEART score history component: A chart review study.

Journal of the American College of Emergency Physicians open·2022
Same author

Traumatic Pneumocephalus Without Skull Fracture From a High-Voltage Electrical Injury.

Cureus·2021
Same author

Commercial and Improvised Pelvic Compression Devices: Applied Force and Implications for Hemorrhage Control.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals·2021
Same journal

Why Dispelling Myths and Misconceptions in Emergency Medicine Matters.

Emergency medicine clinics of North America·2026
Same journal

Myths and Misconceptions in Emergency Medicine.

Emergency medicine clinics of North America·2026
Same journal

Acute Otitis Media-Watch and Wait Is Not a Myth.

Emergency medicine clinics of North America·2026
Same journal

Hot or Not? Myths and Misconceptions About Antipyretics for Pediatric Fever.

Emergency medicine clinics of North America·2026
Same journal

Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.

Emergency medicine clinics of North America·2026
Same journal

Myth: Pretreatment Prevents Intravenous Contrast Reactions in the Emergency Department.

Emergency medicine clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

8.9K

Anticoagulation Reversal.

Erica M Simon1, Matthew J Streitz1, Daniel J Sessions2

  • 1Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr. Fort Sam, Houston, TX 78234, USA.

Emergency Medicine Clinics of North America
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

Emergency physicians need to understand anticoagulant and antiplatelet reversal strategies. This review covers managing bleeding from warfarin, low-molecular-weight heparin, and direct oral anticoagulants.

Keywords:
Anticoagulant reversalHeparinIdarucizumabNovel oral anticoagulantsProthrombin complex concentrateWarfarin

More Related Videos

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.4K
Creation of Reversible Cholestatic Rat Model
09:39

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

15.4K

Related Experiment Videos

Last Updated: Feb 7, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

8.9K
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.4K
Creation of Reversible Cholestatic Rat Model
09:39

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

15.4K

Area of Science:

  • Pharmacology
  • Emergency Medicine
  • Hematology

Background:

  • Anticoagulant and antiplatelet agents are widely prescribed.
  • Patients on these medications have an increased risk of bleeding.
  • Effective management of bleeding complications is crucial in emergency settings.

Purpose of the Study:

  • To review strategies for managing bleeding in patients on anticoagulant and antiplatelet therapy.
  • To provide emergency physicians with essential knowledge on hemostasis and reversal agents.

Main Methods:

  • Literature review of current guidelines and clinical studies.
  • Synthesis of information on warfarin, low-molecular-weight heparin, and direct oral anticoagulant reversal.

Main Results:

  • Detailed review of bleeding management protocols for specific anticoagulant classes.
  • Identification of key reversal agents and their indications.

Conclusions:

  • Emergency physicians require specialized knowledge of anticoagulant reversal.
  • Prompt and appropriate management can mitigate bleeding risks associated with these therapies.