Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
The Hyoid Bone01:12

The Hyoid Bone

5.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K
Spongy Bone01:09

Spongy Bone

8.0K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a clinical decision support system for exercise prescription among cancer survivors: a modified Delphi study.

Journal of cancer survivorship : research and practice·2026
Same author

World Cancer Research Fund /American Institute for Cancer Research Screener algorithm versus standard Score: Association with mortality in colorectal cancer patients.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Evaluation of a multimodal personalized prehabilitation program in colon cancer patients undergoing surgery, focussing on changes in nutritional status, physical fitness and exploring clinical outcomes.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Association between energy availability and sleep quality in elite female and male swimmers: a brief report.

Journal of the International Society of Sports Nutrition·2026
Same author

Exercise effects on lean body mass, muscle strength and functional performance in patients with metastatic breast cancer: the randomized controlled PREFERABLE-EFFECT study.

Breast cancer research : BCR·2026
Same author

Development and Usability of the "FORTEe Get Strong" App to Promote Physical Activity and Health Awareness in Children and Adolescents With Cancer During Intensive Treatment Using an App-Based Approach: Mixed Methods Study.

JMIR serious games·2026

Related Experiment Video

Updated: Feb 7, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K

Bone resorption and bone metastasis risk.

Katlynn M Mathis1, Kathleen M Sturgeon1, Renate M Winkels1

  • 1Pennsylvania State University, Public Health Sciences, 500 University Drive, Hershey, PA 17033, United States.

Medical Hypotheses
|July 25, 2018
PubMed
Summary

Increased bone resorption, indicated by low bone mineral density, may be a modifiable risk factor for breast cancer bone metastasis. Further research is needed to confirm this link and identify interventions during chemotherapy.

More Related Videos

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

6.8K

Related Experiment Videos

Last Updated: Feb 7, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

6.8K

Area of Science:

  • Oncology
  • Bone Biology
  • Metastasis Research

Background:

  • Breast cancer frequently metastasizes to bone, significantly impacting patient survival.
  • The modifiable risk factors for developing bone metastases in breast cancer patients are not well understood.
  • Increased bone resorption, driven by osteoclast activity, is implicated in facilitating tumor cell proliferation within bone.

Purpose of the Study:

  • To investigate the potential role of increased bone resorption as a modifiable risk factor for bone metastasis in breast cancer.
  • To explore the relationship between bone mineral density and the incidence of bone metastases.
  • To examine the impact of chemotherapy on bone mineral density and its implications for metastasis risk.

Main Methods:

  • Review of existing mouse studies demonstrating a correlation between bone mineral density and bone metastasis incidence.
  • Analysis of human studies involving anti-osteoporotic drugs and their effect on osteoclast activity and bone metastases.
  • Consideration of chemotherapy's direct and indirect effects on bone cells and estrogen levels.

Main Results:

  • Mouse models indicate that higher bone mineral density is associated with decreased bone metastasis incidence.
  • Conversely, lower bone mineral density or increased bone resorption correlates with a higher incidence of bone metastases.
  • Anti-osteoporotic drugs show potential in reducing osteoclast activity and preventing bone metastases in human studies.

Conclusions:

  • Increased osteoclast activity, leading to low bone mineral density, is a potential modifiable risk factor for breast cancer bone metastasis.
  • Chemotherapy can exacerbate bone loss through direct effects on bone cells and decreased estrogen levels.
  • Future research should focus on quantifying the risk associated with bone resorption and identifying interventions to balance osteoblast and osteoclast activity during chemotherapy.