Recent progress in analytical capillary isotachophoresis

Area of Science:

• Analytical Chemistry
• Separation Science

Background:

• Analytical Isotachophoresis (ITP) is a powerful separation technique.
• Recent advancements have focused on enhancing its sensitivity and applicability.
• ITP offers unique concentrating capabilities valuable for trace analysis.

Purpose of the Study:

• To provide a comprehensive review of analytical ITP studies published between 2016 and early 2018.
• To assess the current standing of ITP within contemporary separation techniques.
• To highlight the importance of ITP's concentrating capabilities in developing sensitive analytical methods.

Main Methods:

• Literature review of scientific papers on analytical ITP.
• Categorization of studies based on ITP theory, instrumentation, techniques, and applications.
• Analysis of reviewed papers considering their nature, methods, and instrumentation.
• Emphasis on the role of electrolyte system composition in ITP performance.

Main Results:

• The review covers theoretical principles, instrumentation, techniques, and applications of ITP.
• Analytical ITP is positioned as a valuable technique due to its high-sensitivity potential.
• Specific examples and values are provided to illustrate the significance of electrolyte composition.

Conclusions:

• Analytical ITP remains a relevant and promising technique for high-sensitivity analyses.
• The unique concentrating power of ITP is a key factor driving its continued interest and application.
• Further research and development in ITP instrumentation and electrolyte systems are crucial for its advancement.