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Updated: Feb 7, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis
James M Wood1, Daniel P Furkert1, Margaret A Brimble2
1School of Chemical Sciences, University of Auckland, 23 Symonds St, Auckland, 1142, New Zealand. m.brimble@auckland.ac.nz.
Abstract:
Covering: up to April 2018 2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.
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