Related Experiment Video
Updated: Feb 7, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
10.3K
Adjuvant therapy for resected high-risk melanoma
Justin C Moser1, Kenneth F Grossman2
1Division of Hematology and Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Seminars in Cutaneous Medicine and Surgery
|July 25, 2018
Summary
New adjuvant therapies offer hope for high-risk melanoma patients after surgery. This review covers emerging treatments and ongoing research to prevent melanoma recurrence.
Area of Science:
- Oncology
- Dermatology
- Cancer Research
Background:
- Melanoma is an aggressive skin cancer originating from melanocytes.
- Early detection allows for curative surgical resection.
- High-risk melanoma patients face significant recurrence rates post-surgery, with limited options for distant metastasis.
Purpose of the Study:
- To review novel adjuvant therapy options for high-risk resected melanoma.
- To discuss ongoing clinical research in melanoma adjuvant treatment.
- To provide an overview of recent advancements in melanoma recurrence prevention.
Main Methods:
- Literature review of recent clinical trials and studies.
- Analysis of emerging therapeutic strategies in melanoma.
- Synthesis of current research on adjuvant melanoma treatments.
Main Results:
- The landscape of adjuvant melanoma therapy has evolved rapidly.
- New therapeutic agents demonstrate efficacy in the metastatic setting, informing adjuvant strategies.
- Several clinical trials are investigating the role of these new therapies in the adjuvant setting.
Conclusions:
- Adjuvant therapy is crucial for reducing recurrence in high-risk melanoma.
- Emerging treatments represent a significant advancement in managing melanoma.
- Continued research is vital to optimize adjuvant therapy and improve patient outcomes.
Related Concept Videos
01:12Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
01:26Factors Affecting the Risk of Infection
13.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.7K
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
01:26Group Therapy
450
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
450
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
01:22Behavior Therapy
728
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
728