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Updated: Feb 7, 2026
09:58
A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
Published on: May 10, 2018
10.0K
Aripiprazole Lauroxil NanoCrystal ® Dispersion Technology (Aristada Initio ® )
Clinical Schizophrenia & Related Psychoses
|July 25, 2018
Summary
Nonadherence to antipsychotic medications is a challenge in schizophrenia treatment. A new aripiprazole lauroxil formulation eliminates the need for oral overlap, simplifying treatment initiation for long-acting injectable antipsychotics.
Area of Science:
- Psychiatry
- Pharmacology
- Drug Delivery Systems
Background:
- Antipsychotic medication nonadherence significantly impacts schizophrenia treatment outcomes and costs.
- Long-acting injectable (LAI) antipsychotics improve adherence but often require oral overlap during initiation.
- Aripiprazole lauroxil, an LAI, currently necessitates 21 days of oral overlap.
Purpose of the Study:
- To introduce a novel delivery system for aripiprazole lauroxil designed to eliminate the need for oral overlap.
- To present a new one-day regimen for initiating aripiprazole lauroxil treatment.
Main Methods:
- Development of a nano-crystalline milled dispersion delivery system for aripiprazole lauroxil.
- Clinical evaluation of the novel formulation for efficacy and safety during treatment initiation.
Main Results:
- A new nano-crystalline milled dispersion of aripiprazole lauroxil has been approved.
- This formulation allows for a one-day initiation regimen, removing the requirement for oral overlap.
Conclusions:
- The novel nano-crystalline milled dispersion of aripiprazole lauroxil offers a simplified initiation strategy.
- This advancement addresses the challenge of oral overlap in LAI antipsychotic therapy for schizophrenia.
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