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Updated: Feb 7, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Aortic valve calcification and risk of stroke: A systematic review and meta-analysis

Danfeng Zhang1, Xianliang Dai2, Chaoqun Wang3

  • 1Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 26, 2018
PubMed

Insights

Aortic valve calcification (AVC) is linked to increased stroke risk in older adults. However, current evidence is inconsistent, necessitating further large-scale studies to confirm this association.

Area of Science:

  • Cardiovascular Medicine
  • Epidemiology
  • Geriatrics

Background:

  • Aortic valve calcification (AVC) is prevalent in the elderly.
  • AVC is suspected to increase stroke risk, but existing research yields conflicting results.

Purpose of the Study:

  • To conduct a meta-analysis clarifying the association between AVC and stroke risk.
  • To synthesize findings from existing cohort studies.

Main Methods:

  • A systematic literature search was performed in Embase, PubMed, and Cochrane Library for cohort studies.
  • Data from 7 cohort studies involving 21,395 participants and 1025 strokes were analyzed.
  • Risk ratios (RR) and 95% confidence intervals (CIs) were used, with a random-effects model for synthesis.

Main Results:

  • A statistically significant correlation between AVC and stroke was found (RR, 1.20; 95% CI, 1.02-1.40).
  • Low heterogeneity was observed (I² = 6.9%, P = 0.375).
  • Significant results were only apparent in the subgroup with adjusted variables (P = 0.04).

Conclusions:

  • The current data do not definitively establish a causal relationship between AVC and stroke risk.
  • Larger prospective studies are required to validate the AVC-stroke association.

Keywords:
Aortic valve calcificationMeta-analysisStroke

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