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FTO-activated DNA walker for specific Na+ imaging in cancer cells
Mengyu Peng1, Chaoqun Wang2, Zixuan Zhan3
1National and Local Joint Engineering Laboratory for Energy Plant Bio-oil Production and Application, Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China. lvy@scu.edu.cn.
None:
Specific Na+ imaging within cancer cells is of great significance for understanding their physiological state and malignant progression. Despite great success, Na+ imaging methods often face challenges related to specificity and sensitivity. Herein, we designed a fat mass and obesity-associated protein (FTO)-activated DNA walker for the specific imaging of metal ions in cancer cells. Abnormal FTO expression in cancer cells provides high specificity, while the self-amplification mechanism of the DNA walker provides high sensitivity.
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