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Cognitive Dysfunction in Relation to Topography and Burden of Cerebral Microbleeds

Gülseren Büyükşerbetçi1,2, Esen Saka2, Kader Karli Oğuz3

  • 1Department of Neurology, Balıkesir University Hospital, Balıkesir, Turkey.

Noro Psikiyatri Arsivi
|July 26, 2018
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) distribution, not number, impacts cognitive function in elderly patients with white matter lesions (WMLs). Thalamic/cortical CMBs specifically predict language deficits, highlighting location

Area of Science:

  • Neuroimaging
  • Neurology
  • Geriatrics

Background:

  • Cerebral microbleeds (CMBs) contribution to cognitive dysfunction in elderly patients with asymptomatic white matter lesions (WMLs) is unclear.
  • White matter lesions (WMLs) are common in aging brains and can affect cognition.

Purpose of the Study:

  • To investigate the relationship between CMBs, WMLs, cerebral atrophy, and cognitive function in elderly individuals.
  • To determine if the location or number of CMBs is more critical for cognitive impairment.

Main Methods:

  • Retrospective analysis of MRI scans (T2*-gradient-echo) from 85 elderly patients with CMBs.
  • Assessment of cerebral atrophy, CMBs, WMLs, and cognitive domains (attention, executive, memory, visuospatial, language).

Main Results:

  • 42% of patients exhibited impaired global cognition (MMSE score ≤24).
  • Higher WML burden and temporal atrophy were associated with lower MMSE scores.
  • CMB burden in thalamic/cortical regions predicted language dysfunction, while overall CMB load did not correlate with global cognition.

Conclusions:

  • Cognitive dysfunction related to CMBs appears to depend on their anatomical distribution rather than their total count.
  • Specific CMB locations, such as thalamic and cortical regions, may have a greater impact on particular cognitive domains like language.
Keywords:
Cholinergiccortexcorticaldementiagradient echolacunemagnetic resonance imagingmicrobleedwhite matter

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