Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

740
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
740
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

833
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
833
What is an Experiment?01:12

What is an Experiment?

18.9K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.9K
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

242
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
242
Thomson's e/m Experiment01:19

Thomson's e/m Experiment

6.9K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
6.9K
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

1.8K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A neurocognitive account of complex PTSD: self-modelling, affective dysregulation, and implications for MDMA-assisted and targeted psychotherapies.

European journal of psychotraumatology·2026
Same author

Interoceptive active inference and self-representation in social anxiety disorder (SAD): exploring the neurocognitive traits of the SAD self.

Neuroscience of consciousness·2024
Same author

Pain suffering and the self. An active allostatic inference explanation.

Neuroscience of consciousness·2024
Same author

Psychedelics alter metaphysical beliefs.

Scientific reports·2021
Same author

Pain Asymbolia as Depersonalization for Pain Experience. An Interoceptive Active Inference Account.

Frontiers in psychology·2020
Same author

From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses.

Schizophrenia bulletin·2019
Same journal

Perceptual learning without feedback is accompanied with systematic changes in confidence processing.

Neuroscience of consciousness·2026
Same journal

I sync, therefore I am: brain-body synchrony in typical and disordered consciousness.

Neuroscience of consciousness·2026
Same journal

The Rhythmic Embodied Perception Framework of breath, brain, and perception.

Neuroscience of consciousness·2026
Same journal

Temporal recalibration in schizophrenia: a compensatory timing trap?

Neuroscience of consciousness·2026
Same journal

Aidification of the self: a phenomenological approach to machine consciousness through human-robot 'between-ness'.

Neuroscience of consciousness·2026
Same journal

Confidence in naturalistic decision making.

Neuroscience of consciousness·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
05:59

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

Published on: November 4, 2022

2.1K

Self unbound: ego dissolution in psychedelic experience.

Chris Letheby1, Philip Gerrans1

  • 1Department of Philosophy, University of Adelaide, North Terrace, Adelaide, South Australia 5005, Australia.

Neuroscience of Consciousness
|July 26, 2018
PubMed
Summary
This summary is machine-generated.

Psychedelic drugs can induce ego dissolution, a state where the sense of self dissolves. This experience suggests the self is a cognitive construct, not an enduring entity, arising from predictive processing models.

Keywords:
LSDbinding and multisensory integrationhallucinogenpsilocybinpsychedelicself

More Related Videos

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

18.6K
A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL
07:04

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL

Published on: May 23, 2014

12.1K

Related Experiment Videos

Last Updated: Feb 7, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
05:59

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

Published on: November 4, 2022

2.1K
Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

18.6K
A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL
07:04

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL

Published on: May 23, 2014

12.1K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Philosophy of Mind

Background:

  • Psychedelic drug users frequently report experiences of 'ego dissolution,' characterized by a diminished or absent sense of self.
  • Investigating ego dissolution offers insights into the neuroscientific basis of self-awareness.

Purpose of the Study:

  • To explain ego dissolution through the lens of predictive processing and hierarchical models.
  • To re-evaluate the nature of the self-model and its role in cognitive function.

Main Methods:

  • Theoretical analysis integrating predictive processing principles with theories of the 'integrative self' and self-binding.
  • Examining the functional role of the self-model in cognitive integration.

Main Results:

  • Ego dissolution is explained as a breakdown in the predictive model's positing of a stable self.
  • The self-model is characterized as a functional, albeit illusory, construct serving cognitive unification.

Conclusions:

  • The self is not a fundamental entity but a useful representation for integrating cognitive processes.
  • Ego dissolution experiences highlight the binding function of the self-model, demonstrating the non-existence of a persistent self.