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Related Experiment Video

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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Ultra-Low-Dose Sparse-View Quantitative CT Liver Perfusion Imaging.

Esmaeil Enjilela1, Ting-Yim Lee1,2, Jiang Hsieh3

  • 1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada.

Tomography (Ann Arbor, Mich.)
|July 26, 2018
PubMed
Summary
This summary is machine-generated.

Reducing computed tomography (CT) liver perfusion imaging radiation dose by using fewer x-ray projections is feasible. A one-third reduction in projections with either filtered backprojection (FBP) or compressed sensing (CS) maintained accurate hepatic arterial blood flow (HABF) assessment in hepatocellular carcinoma (HCC).

Keywords:
compressed sensinghepatic arterial blood flowquantitative liver perfusion imagingradiation dose reductionsparse-view image reconstruction

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Area of Science:

  • Medical Imaging
  • Radiology
  • Hepatobiliary Imaging

Background:

  • Computed tomography (CT) liver perfusion imaging is crucial for assessing hepatocellular carcinoma (HCC).
  • Reducing radiation dose in CT liver perfusion imaging is desirable but can introduce aliasing artifacts.
  • Artifacts from undersampled projections may impact hepatic perfusion measurements, particularly hepatic arterial blood flow (HABF).

Purpose of the Study:

  • To investigate the impact of projection undersampling on HABF assessment in HCC.
  • To compare image reconstruction methods, filtered backprojection (FBP) and compressed sensing (CS), under undersampled conditions.
  • To determine the feasibility of dose reduction in dynamic contrast-enhanced (DCE) CT liver perfusion imaging.

Main Methods:

  • Dynamic contrast-enhanced (DCE) liver CT data from an HCC patient were reconstructed using varying projection sets (full-view, one-third, one-fourth).
  • Reconstructions were performed using standard filtered backprojection (FBP) and compressed sensing (CS).
  • Hepatic arterial blood flow (HABF) maps were generated using a model-based deconvolution algorithm and compared across protocols.

Main Results:

  • Reconstruction with one-third fewer projections (328-view) using either FBP or CS resulted in HABF measurements within 5% of the full-view reference.
  • Tumor size measurements were identical between the 328-view protocols (FBP and CS) and the full-view reference.
  • A one-fourth reduction in projections (246-view) led to significant (>20%) differences in anatomical and functional assessments compared to the full-view protocol.

Conclusions:

  • Computed tomography (CT) liver perfusion imaging for HCC can be performed with a 67% reduction in radiation dose (using one-third projections).
  • Both FBP and CS reconstruction methods are viable for maintaining diagnostic accuracy with undersampled data.
  • This preliminary study suggests a significant potential for radiation dose reduction in liver perfusion CT without compromising HABF assessment accuracy.