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Updated: Feb 7, 2026
08:43
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
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Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
Inbal E Biton1, Noa Stettner1,2,3, Ori Brener1
1Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Tomography (Ann Arbor, Mich.)
|July 26, 2018
Summary
This study introduces a noninvasive magnetic resonance imaging (MRI) technique to assess colon inflammation in mice with inflammatory bowel disease (IBD). The MRI method offers an objective alternative to endoscopy for evaluating colitis activity.
Area of Science:
- Gastroenterology
- Medical Imaging
- Inflammatory Bowel Disease Research
Background:
- Inflammatory bowel disease (IBD) involves chronic gastrointestinal inflammation.
- Assessing colonic inflammation is crucial for managing IBD.
- Current endoscopic methods carry risks like perforation and are operator-dependent.
Purpose of the Study:
- To develop a noninvasive, objective, and quantitative magnetic resonance imaging (MRI) technique.
- To assess mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model.
- To provide an improved method for evaluating IBD activity.
Main Methods:
- Induced acute colitis in mice using dextran sodium sulfate.
- Characterized colitis using multisection magnetic resonance colonography.
- Correlated MRI findings with endoscopic and histopathological evaluations.
Main Results:
- Demonstrated the feasibility of using MRI for assessing colitis.
- Showcased MRI's potential for objective and quantitative evaluation of mucosal inflammation.
- Established correlation between MRI, endoscopy, and histology.
Conclusions:
- Developed a noninvasive MRI technique for evaluating colitis in a mouse model.
- MRI offers a promising objective alternative to invasive endoscopic assessments for IBD.
- This technique can aid in disease activity assessment and monitoring.
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