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Updated: Feb 7, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
Published on: July 25, 2025
MINIMAL INVASIVE DRAINAGE TECHNIQUE FOR LARGE EXPANDING SUBRETINAL GAS BUBBLE
Radwan Ajlan1, Jean-Daniel Arbour, Karim Hammamji
1Department of Ophthalmology, University of Montreal Health Center (CHUM), University of Montreal, Montreal, Québec, Canada.
This study presents a novel, minimally invasive technique to drain large subretinal gas bubbles, a rare complication of retinal detachment surgery. The successful office-based procedure restored vision and reattached the retina.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Minimally Invasive Procedures
Background:
- Subretinal gas injection is a rare but serious complication during retinal detachment surgery.
- Prompt management is crucial to prevent vision loss and retinal damage.
Observation:
- A case report details a 40-year-old male with bullous rhegmatogenous retinal detachment.
- Inadvertent large subretinal gas injection occurred during cryo-pneumatic retinopexy.
- The patient presented with a large expanding subretinal gas bubble.
Findings:
- A minimally invasive technique successfully drained the subretinal gas bubble in an office-based setting.
- Post-procedure, perfluoropropane (C3F8) gas was injected, and the macula remained attached.
- Complete retinal reattachment and 20/20 vision were achieved within 45 days.
Implications:
- This technique offers a potential office-based solution for managing subretinal gas complications.
- It may be an alternative when immediate vitrectomy is not feasible.
- Surgeons should be proficient in managing potential complications if attempting this procedure.
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