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Management of dabigatran after overdosage: two case reports and suggestions for monitoring

Paul Billoir1, Christophe Girault2,3, Virginie Barbay4

  • 1Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|July 26, 2018
PubMed

: Bleeding is the main complication of anticoagulant treatments as dabigatran etexilate. In patients with atrial fibrillation, dabigatran, at certain doses, has been associated with similar rates of stroke and embolism, and a lower rate of major hemorrhage compared to warfarin. Before the recent possibility of reversing the anticoagulant effect of dabigatran with idarucizumab, prothrombin complex concentrate (PCC) was the main available treatment in cases of severe bleeding or emergency surgery . We describe two different cases with very high overdosage in which PCC or idarucizumab was used to reverse the effect of dabigatran etexilate.

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