Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenal function in tuberculosis.

M E Ellis, F Tayoub

    British Journal of Diseases of the Chest
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Tuberculosis impairs adrenal function, causing low cortisol and dehydroepiandrosterone (DHEA) levels in Zulus. Chemotherapy improved corticosteroid function, but not DHEA, with rifampicin potentially hindering recovery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A QTL on chromosome 6A in bread wheat (Triticum aestivum) is associated with longer coleoptiles, greater seedling vigour and final plant height.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2007
    Same author

    Mercuric ion attenuates nuclear factor-kappaB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicity.

    Toxicology and applied pharmacology·2001
    Same author

    Fungal endocarditis: evidence in the world literature, 1965-1995.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000
    Same author

    The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis.

    Toxicology and applied pharmacology·1999
    Same author

    Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.

    Infection and immunity·1999
    Same author

    Activation of NF-kappaB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway.

    Toxicology and applied pharmacology·1999
    Same journal

    Apical pulmonary fibrosis in psoriasis.

    British journal of diseases of the chest·1988
    Same journal

    Progressive apical pleural fibrosis: a 'constrictive' ventilatory defect.

    British journal of diseases of the chest·1988
    Same journal

    Induction of bronchial hyperresponsiveness following smoke inhalation injury.

    British journal of diseases of the chest·1988
    Same journal

    Chronic beryllium disease in identical twins.

    British journal of diseases of the chest·1988
    Same journal

    Pleuropulmonary haemangiopericytoma masquerading as a post-infective encysted pleural effusion.

    British journal of diseases of the chest·1988
    Same journal

    Massive haemoptysis in the acquired immunodeficiency syndrome.

    British journal of diseases of the chest·1988
    See all related articles

    Area of Science:

    • Endocrinology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Acute pulmonary tuberculosis can significantly impact endocrine function.
    • Adrenal insufficiency, characterized by suboptimal cortisol and low dehydroepiandrosterone (DHEA) levels, is a potential complication.
    • Understanding these effects is crucial for managing tuberculosis patients.

    Purpose of the Study:

    • To investigate the adrenal corticosteroid and androgen function in African Zulus with acute pulmonary tuberculosis.
    • To assess the impact of antituberculous chemotherapy on adrenal function.
    • To compare the effects of rifampicin-containing versus non-rifampicin antituberculous regimens on adrenal recovery.

    Main Methods:

    • Study included 41 African Zulu patients diagnosed with acute pulmonary tuberculosis.

    Related Experiment Videos

  • Assessed cortisol response to Synacthen (cosyntropin stimulation test) and plasma dehydroepiandrosterone (DHEA) levels.
  • Evaluated adrenal function before and after a 2-week course of antituberculous chemotherapy.

    • Main Results:

    • Initially, 55% of patients showed a suboptimal cortisol response, and all had very low plasma DHEA levels.
    • After 2 weeks of chemotherapy, impaired cortisol response reduced to 30%, indicating improved corticosteroid function.
    • Adrenal androgen function (DHEA levels) did not improve in any patients post-treatment. Rifampicin-containing treatment was associated with less improvement in corticosteroid function compared to regimens without rifampicin.

    Conclusions:

    • Acute pulmonary tuberculosis significantly impairs adrenal corticosteroid and androgen function.
    • Antituberculous chemotherapy partially restores corticosteroid function but does not improve adrenal androgen levels.
    • Rifampicin may have a negative impact on the recovery of adrenal corticosteroid function in tuberculosis patients.