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A mesodermal fate map for adipose tissue.

Zachary L Sebo1, Elise Jeffery2, Brandon Holtrup1

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.

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|July 27, 2018
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Summary
This summary is machine-generated.

Most brown adipocytes originate from outside the central dermomyotome. Adipocyte precursors (APs) from different lineages within the same fat depot respond similarly to high-fat diets, suggesting developmental history doesn't dictate function.

Keywords:
AdipocyteAdiposeFate mapLineage tracingMesoderm

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Area of Science:

  • Developmental biology
  • Adipose tissue biology
  • Genetics

Background:

  • The embryonic origins of fat depots and functional differences in adipocyte lineages are not well understood.
  • Investigating the developmental pathways that specify distinct fat depots and adipocyte functions is crucial for understanding metabolic health.

Purpose of the Study:

  • To investigate the embryonic origins of adipocyte lineages using a mouse model.
  • To determine if developmental origins influence adipocyte function, particularly in response to dietary changes.

Main Methods:

  • Utilized a Cre/Lox-based genetic strategy in mice to trace the developmental fate of mesodermal progenitor cells.
  • Analyzed the contribution of different embryonic germ layers to various fat depots, including brown adipose tissue.
  • Assessed the response of distinct adipocyte precursor populations to a high-fat diet.

Main Results:

  • Less than 50% of interscapular brown adipocytes are derived from central dermomyotome progenitors.
  • Adipocyte lineages diverge spatially as early as gastrulation, with depot-specific origins differing between sexes for perigonadal fat.
  • Adipocyte precursors from distinct lineages within the same depot show similar responses to a high-fat diet.

Conclusions:

  • Adipose tissue patterning is influenced by developmental origins, but these origins do not strictly determine adipocyte lineage cell behavior.
  • Functional differences among adipocyte lineages may not solely be dictated by their embryonic source.
  • Findings suggest plasticity in adipocyte precursor responses regardless of developmental history.