Related Experiment Video
Updated: Feb 7, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
M3RNA Drives Targeted Gene Delivery in Acute Myocardial Infarction
Raman Deep Singh1,2, Matthew L Hillestad1,2, Christopher Livia1,2,3
11 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Impact Statement:
The M3RNA (microencapsulated modified messenger RNA) platform is an approach to deliver messenger RNA (mRNA) in vivo, achieving a nonintegrating and viral-free approach to gene therapy. This technology was, in this study, tested for its utility in the myocardium, providing a unique avenue for targeted gene delivery into the freshly infarcted myocardial tissue. This study provides the evidentiary basis for the use of M3RNA in the heart through depiction of its performance in cultured cells, healthy rodent myocardium, and acutely injured porcine hearts. By testing the technology in large animal models of infarction, compatibility of M3RNA with current coronary intervention procedures was verified.
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