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A Two-Photon H2 O2 -Activated CO Photoreleaser.
Yong Li1, Yingzheng Shu1, Muwen Liang1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.
Angewandte Chemie (International Ed. in English)
|July 27, 2018
Summary
Researchers developed a novel two-photon carbon monoxide (CO) photoreleaser activated by hydrogen peroxide (H2O2). This system enables controlled CO release, overcoming challenges associated with CO inhalation therapy and demonstrating vasodilation effects.
Area of Science:
- Biomedical Engineering
- Photochemistry
- Pharmacology
Background:
- Carbon monoxide (CO) shows therapeutic potential but faces challenges in safe administration due to high hemoglobin affinity.
- Controlled release of CO is crucial for therapeutic applications to avoid side effects and optimize biological functions.
Purpose of the Study:
- To develop a platform for controlled carbon monoxide delivery.
- To create a system sensitive to oxidative stress biomarkers and external triggers for CO release.
Main Methods:
- Development of a two-photon H2O2-activated CO photoreleaser (FB).
- Utilized hydrogen peroxide (H2O2) as a specific trigger for CO release.
- Incorporated photo-control for precise regulation of CO release.
Main Results:
- The developed FB system demonstrated highly sensitive and specific H2O2 sensing.
- Photocontrollable CO release was achieved with the FB system.
- The vasodilation effect of released CO against angiotensin II was successfully demonstrated.
Conclusions:
- The FB photoreleaser offers a promising strategy for safe and effective carbon monoxide therapy.
- This system enables targeted CO delivery modulated by oxidative stress and light.
- Further research into CO-based therapeutics is warranted.
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