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Radiation-Associated Sarcoma of the Neck: Case Series and Systematic Review
Lawrence Williams1, Lyubov Tmanova1, Wojciech K Mydlarz2,3
11 Department of Otolaryngology - Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.
The Annals of Otology, Rhinology, and Laryngology
|July 27, 2018
Summary
Complete surgical resection is key for treating rare radiation-associated soft tissue sarcomas of the neck (RASN). Further research is needed due to limited data on RASN management and outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Radiation-associated soft tissue sarcomas of the neck (RASN) are rare and aggressive tumors.
- These tumors can develop years after radiation therapy to the neck region.
Purpose of the Study:
- To review institutional cases of RASN.
- To systematically review the existing literature on RASN management and outcomes.
Main Methods:
- Retrospective chart review of 3 institutional patients with RASN.
- Systematic literature review using MEDLINE, Ovid, Cochrane Library, and Embase.
Main Results:
- Institutional patients presented with neck masses 6-26 years post-radiation.
- All patients underwent successful surgical resection with clear margins.
- Systematic review identified 9 relevant articles, but studies were small and heterogeneous, limiting data pooling.
- Complete surgical extirpation was highlighted as crucial.
Conclusions:
- Complete surgical resection is the primary treatment for RASN.
- Limited data currently exists regarding the optimal management and long-term outcomes for RASN patients.
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