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Updated: Feb 7, 2026
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
ACUTE RETINAL NECROSIS ASSOCIATED WITH HERPES ZOSTER VACCINATION
Moreno Menghini1, Vignesh Raja1, Jeremy Raiter2
1Department of Ophthalmology, Sir Charles Gairdner Hospital, Hospital Ave, Western Australia, Australia.
Purpose:
To report a case of Zostavax-associated acute retinal necrosis in a patient with chronic lymphocytic leukemia.
Methods:
Case report.
Patients:
A 76-year-old white man.
Results:
Unilateral acute retinal necrosis with obliterative angiopathy developed in close proximity of a Zostavax vaccine. Treatment with valacyclovir hydrochloride (1 g orally three times a day) and intravitreal ganciclovir (4 mg/0.1 mL) was initiated on presentation. Because of continuous increase of the retinal necrosis, patient was switched to intravenous acyclovir (7.5 mg/kg body weight, adapted to reduced glomerular filtration rate) and given intravitreal foscarnet (2.4 mg/0.1 mL). Despite being on maximal antiviral therapy, the patient suffered a central retinal artery occlusion.
Discussion:
Acute retinal necrosis is a severe complication and potentially blinding disease of herpes zoster, and can occur in association with herpes zoster immunization, in particular, in immune suppressed patients.
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