Related Experiment Video

Updated: Feb 7, 2026

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

17.0K

Rotavirus vaccination and short-term risk of adverse events in US infants

J Bradley Layton1,2, Anne M Butler3,4, Catherine A Panozzo5

  • 1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Research Triangle Park, North Carolina.

Paediatric and Perinatal Epidemiology
|July 27, 2018
PubMed

Insights

Rotavirus vaccination (RV) in infants showed no increased risk for intussusception or other serious adverse events. A slight increase in otitis media risk was observed, particularly with the RV1 formulation.

Area of Science:

  • Pediatric Vaccinology
  • Public Health
  • Epidemiology

Background:

  • Rotavirus vaccines (RV) are crucial for preventing severe rotavirus gastroenteritis in infants.
  • Understanding the short-term safety profile of RV, including different formulations, is essential for public health recommendations.

Purpose of the Study:

  • To evaluate the short-term risk of adverse events following rotavirus vaccination in infants.
  • To compare adverse event risks between pentavalent (RV5) and monovalent (RV1) rotavirus vaccine formulations.

Main Methods:

  • A cohort study of US newborns (2006-2014) receiving diphtheria-tetanus-pertussis vaccine (DTaP) was conducted.
  • Infants were monitored for 30 days post-vaccination for intussusception, gastrointestinal events, seizures, Kawasaki disease, thrombocytopenia, otitis media, and hospitalizations.
  • Cox proportional hazards models were used to compare risks between DTaP+RV and DTaP alone, and between RV5 and RV1.

Main Results:

  • Over 1 million DTaP doses were analyzed, with 79.2% receiving concurrent RV (94.1% RV5).
  • Absolute risks of serious outcomes were very low.
  • No consistent increased risk of intussusception or other adverse events was found with RV+DTaP compared to DTaP alone, except for a small increase in otitis media after dose 2.
  • The increased otitis media risk was less pronounced with RV5 compared to RV1.

Conclusions:

  • Rotavirus vaccination is not associated with an increased risk of intussusception or other major adverse events.
  • A potential small increase in otitis media risk may be associated with rotavirus vaccination, particularly the RV1 formulation.
  • These findings support the overall safety of rotavirus vaccines in infants.
Abstract

Keywords:
administrative claimsepidemiologyimmunisationintussusceptionsafety

More Related Videos

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.7K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.0K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
51.8K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
815
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
4.2K