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Updated: Feb 7, 2026
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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
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Association between Oral Candida and Bacteriome in Children with Severe ECC
J Xiao1, A Grier2, R C Faustoferri1
11 Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Journal of Dental Research
|July 28, 2018
Summary
The opportunistic fungus Candida albicans, often found in children with severe early childhood caries (S-ECC), promotes a harmful oral bacterial community. This interaction increases caries risk and virulence factor activity, highlighting the need for antifungal strategies.
Area of Science:
- Microbiology
- Oral Health
- Mycology
Background:
- Candida albicans is frequently found in children with severe early childhood caries (S-ECC).
- Previous research indicated the cariogenic potential of C. albicans and its synergy with Streptococcus mutans.
- The influence of C. albicans on the overall oral bacterial community in S-ECC remains unclear.
Purpose of the Study:
- To investigate how Candida albicans affects the oral microbiota composition and diversity in children with S-ECC.
- To explore the relationship between C. albicans, bacterial communities, and virulence factors in S-ECC.
- To assess the role of maternal microbiota in children's oral health.
Main Methods:
- 16S rRNA amplicon sequencing was used to analyze saliva and supragingival plaque microbiota.
- Samples were collected from 39 children (21 S-ECC, 18 caries-free) and 33 mothers (17 S-ECC, 16 caries-free).
- Microbial community composition, diversity, and glucosyltransferase activity were analyzed.
Main Results:
- C. albicans presence correlated with a highly acidogenic and acid-tolerant oral bacterial community in S-ECC.
- Increased abundance of Streptococcus mutans, Lactobacillus/Scardovia, Veillonella, and Prevotella was observed with C. albicans.
- Elevated glucosyltransferase activity and altered Actinomyces levels were noted in the presence of C. albicans.
Conclusions:
- C. albicans plays a significant role in shaping the oral bacteriome associated with S-ECC.
- Fungal-bacterial interactions are crucial in S-ECC pathogenesis, influencing virulence factor activity.
- Maternal oral microbiota composition significantly influences children's oral microbiota, suggesting vertical transmission and shared risk factors.
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