Effect of ACTH-(4-10) on equilibrium compensation after unilateral labyrinthectomy in the squirrel monkey

Daily injection of ACTH-(4-10) was given to squirrel monkeys for a 28 day period to modify the characteristics of the post-unilateral labyrinthectomy symptoms along the course of the equilibrium compensation. When compared to the results of the control group, the ACTH-(4-10) injection groups (daily dose 250 micrograms/kg or 500 micrograms/kg) showed a significant improvement of acquisition and maintenance of compensation both in the spinal locomotor balance function and the oculomotor balance function.