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Updated: Jul 25, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Long-term potentiation and depression in hippocampal slices
Abstract:
Antidromic stimulation of hippocampal CA 1 cells, in the presence of Mg2+ to eliminate synaptic transmission and with a pattern of impulses which when applied via a synaptic pathway produced long-term potentiation, was found to decrease the response of the CA 1 cells to subsequent synaptic activation. It was found that stimulation via synapses with the same pattern of stimuli caused long-term potentiation in normal conditions but not in the presence of 25 mM Mg2+.
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