Palisaded Encapsulated Neuroma: An Unusual Presentation.

Area of Science:

• Dermatopathology
• Surgical Pathology
• Oncology

Background:

• Palisaded encapsulated neuroma (PEN) is a rare, benign neural tumor of the skin.
• PEN typically presents as a solitary, skin-colored papule or nodule.
• Clinical differential diagnoses include neurofibroma, melanocytic nevi, and cutaneous schwannoma.

Observation:

• This study reports an unusual case of multifocal cutaneous PENs.
• The patient presented with multiple lesions rather than the typical solitary presentation.
• The clinical presentation mimicked other benign and potentially malignant skin neoplasms.

Findings:

• Histopathological examination is crucial for definitive diagnosis of PEN.
• Multifocal PEN can be distinguished from cutaneous schwannomas through detailed histopathology.
• Specific histopathological features aid in differentiating PEN from other neural tumors.

Implications:

• Recognizing multifocal PEN is important for accurate diagnosis and management.
• Histopathology remains the gold standard for differentiating PEN from clinically similar lesions.
• This case highlights the importance of considering rare presentations of common skin tumors.