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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

613
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

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Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
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Peripartum Cardiomyopathy: an Update.

Feriel Azibani1, Karen Sliwa2,3

  • 1Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, 4th floor Chris Barnard Building, Cape Town, South Africa. feriel.azibani@uct.ac.za.

Current Heart Failure Reports
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PubMed
Summary

Peripartum cardiomyopathy (PPCM) is heart failure during late pregnancy or postpartum. New data highlight endothelial function

Keywords:
Acute heart failureBiomarkerEthnicityPeripartum cardiomyopathyPregnancyRegistry

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Area of Science:

  • Cardiology
  • Obstetrics
  • Genetics

Background:

  • Peripartum cardiomyopathy (PPCM) is a rare form of heart failure.
  • It occurs in the final month of pregnancy or within five months postpartum.
  • The exact cause of PPCM remains idiopathic.

Purpose of the Study:

  • To review recent findings on PPCM pathogenesis and management.
  • To highlight diagnostic and prognostic biomarkers for PPCM.
  • To discuss the role of endothelial function in PPCM.

Main Methods:

  • Review of recent scientific literature and clinical reports.
  • Analysis of data from the first international PPCM registry.
  • Examination of clinical trial data (NCT02590601).

Main Results:

  • Endothelial dysfunction is increasingly implicated in PPCM pathogenesis.
  • Global patient presentations are similar, but management varies.
  • Despite treatment advances, a subset of women experience mortality or incomplete cardiac recovery.

Conclusions:

  • Multi-center and international registries are crucial for advancing understanding of PPCM incidence, pathogenesis, and prognosis.
  • Further research is needed to improve outcomes for all affected women.
  • Biomarkers play a key role in PPCM diagnosis and prognosis.