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Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
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Printable Graphene Oxide Micropatterns for a Bio-Subretinal Chip
Jia-Wei Yang1,2, Ming-Liang Tseng2, Yu-Min Fu3
1Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Advanced Healthcare Materials
|July 28, 2018
Summary
Researchers developed a new method using inkjet printing to create graphene oxide micropatterns on artificial retinal chips. This technique improves retinal pigment epithelium cell growth, enhancing artificial retina function for treating blindness.
Area of Science:
- Biomedical Engineering
- Materials Science
- Ophthalmology
Background:
- Implantable artificial subretinal chips are a promising treatment for retinal diseases.
- Improving cell integration and long-term function of these devices remains a significant challenge.
Purpose of the Study:
- To develop a method for enhancing the biocompatibility and functionality of implantable retinal chips.
- To improve the attachment, growth, and viability of retinal pigment epithelium (RPE) cells on microelectrodes.
Main Methods:
- Utilized inkjet printing technology to create graphene oxide (GO) micropatterns on the microelectrodes of a photovoltaic-powered implantable retinal chip.
- Cultured human RPE cells on the GO-patterned microelectrodes.
Main Results:
- GO micropatterns facilitated specific attachment and growth of RPE cells on each microelectrode.
- Enhanced RPE cell proliferation, viability, and tight junction formation were observed.
- Demonstrated a simple surface-coating technology for improved cell integration.
Conclusions:
- Inkjet-printed GO micropatterns offer a viable strategy for improving the performance of implantable retinal prostheses.
- This surface modification technique paves the way for fully integrated, biocompatible retinal implants for long-term use.
- The approach has significant potential for retina tissue engineering and therapeutic applications.
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