Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A.

Cellular and molecular life sciences : CMLS·2024
Same author

LncRNAs-circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

Profiling mitochondria-polyribosome lncRNAs associated with pluripotency.

Scientific data·2023
Same author

Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.

Cell proliferation·2022
Same author

Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA <i>H19</i>-Fetal Mitogen <i>IGF2</i> Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy.

Cells·2022
Same author

Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia.

Cell death & disease·2022

Related Experiment Video

Updated: Feb 7, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Long noncoding RNAs and their epigenetic function in hematological diseases.

Hanying Huang1, Jingnan Sun1,2, Yunpeng Sun3

  • 1Cancer Center, First Hospital of Jilin University, Changchun, Jilin, China.

Hematological Oncology
|July 28, 2018
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial epigenetic regulators in blood cancers. Understanding their mechanisms offers new therapeutic targets for hematological malignancies.

Keywords:
epigeneticslong noncoding RNAmalignant hematological diseases

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.6K

Related Experiment Videos

Last Updated: Feb 7, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.6K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Hematology

Background:

  • Long noncoding RNAs (lncRNAs) play significant roles in cellular processes.
  • Epigenetic modifications, unlike genetic mutations, are reversible.
  • Hematological diseases involve complex regulatory pathways.

Purpose of the Study:

  • To review the function of lncRNAs in malignant hematologic diseases.
  • To summarize the epigenetic mechanisms regulated by lncRNAs.
  • To highlight the therapeutic potential of targeting lncRNAs in blood cancers.

Main Methods:

  • Literature review of recent discoveries.
  • Analysis of lncRNA functions in hematological malignancies.
  • Examination of epigenetic regulatory roles.

Main Results:

  • lncRNAs are key regulators of development, differentiation, and metastasis in blood cancers.
  • Epigenetic mechanisms involving lncRNAs are frequently reversible.
  • lncRNAs offer potential as therapeutic targets.

Conclusions:

  • lncRNAs are critical epigenetic regulators in hematological malignancies.
  • The reversible nature of lncRNA epigenetic modifications presents therapeutic opportunities.
  • Targeting lncRNAs may lead to novel treatments for blood cancers.