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Updated: Jul 11, 2025
07:20
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
495
LncRNAs-circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers
Shanshan Liu1,2, Benzheng Jiao3,4, Hongguang Zhao4
1Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Cancer Center, First Hospital, Jilin University, Changchun, 130021, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 8, 2023
Summary
Cancer cells reprogram lipid metabolism to fuel growth and resistance. Dysregulated long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) control this process, offering new therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Metabolic Research
Background:
- Lipid metabolic reprogramming is a key hallmark of cancer, supporting tumor growth, metastasis, and treatment resistance.
- This metabolic shift is crucial for generating energy, building cellular components, and maintaining redox balance in cancer cells.
- Emerging evidence implicates non-coding RNAs, particularly lncRNAs and circRNAs, in orchestrating cancer lipid metabolism.
Purpose of the Study:
- To review current research on aberrant lncRNAs and circRNAs in cancer lipid metabolic reprogramming.
- To elucidate the regulatory targets and mechanisms of these non-coding RNAs in lipid metabolism.
- To highlight the clinical significance of non-coding RNA-mediated lipid metabolism modulation in cancer.
Main Methods:
- Literature review of studies investigating lncRNAs, circRNAs, and lipid metabolism in cancer.
- Analysis of research findings on the expression patterns and functional roles of specific lncRNAs and circRNAs.
- Synthesis of information regarding their molecular targets and downstream effects on cancer cell physiology.
Main Results:
- Numerous lncRNAs and circRNAs are aberrantly expressed in various cancers, directly impacting lipid metabolic pathways.
- These non-coding RNAs regulate key enzymes and transcription factors involved in lipid synthesis, uptake, and oxidation.
- Specific lncRNAs and circRNAs have been linked to cancer progression, metastasis, and chemoresistance via lipid metabolism modulation.
Conclusions:
- Dysregulated lncRNAs and circRNAs are critical regulators of cancer lipid metabolism.
- Targeting these non-coding RNAs presents a promising strategy for developing novel cancer theranostics.
- Further research into ncRNA-lipid metabolism interactions can uncover new avenues for cancer treatment.
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