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Pilot Analysis of Early Lactobacillus rhamnosus GG for Infant Colic Prevention

Michael D Cabana1,2,3, Michelle McKean1, Amy L Beck1

  • 1Department of Pediatrics.

Journal of Pediatric Gastroenterology and Nutrition
|July 28, 2018
PubMed

Insights

This pilot study found that Lactobacillus rhamnosus GG (LGG) supplementation did not prevent infant colic. Early LGG intake showed no significant difference in colic rates compared to a control group.

Area of Science:

  • Pediatrics
  • Microbiome research
  • Gastroenterology

Background:

  • Infant colic is a common condition affecting newborns.
  • Probiotics, such as Lactobacillus rhamnosus GG (LGG), are explored for potential health benefits in infants.
  • The efficacy of LGG in preventing infant colic requires further investigation.

Purpose of the Study:

  • To assess the effectiveness of Lactobacillus rhamnosus GG (LGG) supplementation in preventing infant colic.
  • To analyze secondary data from a pilot study on LGG and infant health outcomes.

Main Methods:

  • A secondary analysis of a pilot study involving 184 infants.
  • Infants received daily doses of 10 billion colony-forming units of LGG or a control for the first six months.
  • Colic diagnosis was based on parent-reported symptoms or physician diagnosis before four months of age.

Main Results:

  • Overall, 18 out of 184 infants (9.8%) were diagnosed with colic.
  • No statistically significant differences in colic incidence were observed between the LGG and control groups.
  • Colic rates based on symptoms, physician diagnosis, or combined criteria did not differ significantly between groups (P > 0.13).

Conclusions:

  • Early infant supplementation with Lactobacillus rhamnosus GG (LGG) does not appear to prevent the development of colic.
  • Further research may be needed to explore other probiotic strains or interventions for infant colic.

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