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Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
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The development of local circuits in the neocortex: recent lessons from the mouse visual cortex
Maxime Chevée1, Solange P Brown2
1Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Current Opinion in Neurobiology
|July 28, 2018
Summary
Understanding how specific synaptic connections form in the neocortex is key to brain function. This study investigates the developmental processes establishing connections between excitatory neurons in the mouse visual cortex.
Area of Science:
- Neuroscience
- Developmental Biology
- Computational Neuroscience
Background:
- Precise synaptic connections in the neocortex are crucial for functions like perception, learning, memory, and problem-solving.
- The specific patterns of these connections are fundamental to neural computations.
- The developmental mechanisms generating this synaptic specificity remain largely unknown.
Purpose of the Study:
- To examine the cell-type, subcellular, and synaptic specificity required for mature cortical connectivity.
- To elucidate the developmental processes establishing synaptic connections among excitatory cortical projection neurons.
Main Methods:
- Utilized the primary visual cortex of the mouse as a model system.
- Focused on recent progress in understanding circuit development.
Main Results:
- Considered the requirements for mature cortical connectivity patterns.
- Reviewed advancements in understanding the establishment of excitatory cortical neuron connections.
Conclusions:
- The study provides insights into the formation of specific synaptic connections in the neocortex.
- Understanding these developmental mechanisms is essential for comprehending cortical circuit function.
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