Related Experiment Video
Updated: Feb 7, 2026

Automating ChIP-seq Experiments to Generate Epigenetic Profiles on 10,000 HeLa Cells
Published on: December 10, 2014
The Sierra Platinum Service for generating peak-calls for replicated ChIP-seq experiments
Daniel Wiegreffe1, Lydia Müller2, Jens Steuck3
1Image and Signal Processing Group, Department of Computer Science, University of Leipzig, Augustusplatz 10, 04109, Leipzig, Germany. daniel@bioinf.uni-leipzig.de.
Objective:
Sierra Platinum is a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering. The required computing resources are optimized but still may exceed the resources available to researchers at biological research institutes.
Results:
Sierra Platinum Service provides the full functionality of Sierra Platinum: using a web interface, a new instance of the service can be generated. Then experimental data is uploaded and the computation of the peaks is started. Upon completion, the results can be inspected interactively and then downloaded for further analysis, at which point the service terminates.
Related Concept Videos
Replication in Eukaryotes
DNA Replication
Replication in Prokaryotes
DNA replication...
Chromosome Replication
Replication in Prokaryotes
The DNA Replication Fork
Restarting Stalled Replication Forks

