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Updated: Feb 7, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

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Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug

W Scott Moye-Rowley1

  • 1Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. scott-moye-rowley@uiowa.edu.

Current Genetics
|July 30, 2018
PubMed

Insights

The transcription factor Pdr1 regulates drug resistance in Candida glabrata yeast. Its activity is controlled by negative inputs, but the reasons for this regulation are not fully understood.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Pdr1 is a key transcription factor regulating drug resistance in Candida glabrata.
  • Its activity is modulated by various control mechanisms, acting as a positive regulator.

Purpose of the Study:

  • To review the multiple control mechanisms that modulate the function of the Pdr1 transcription factor.
  • To highlight the negative inputs that restrain Pdr1 activity and their potential loss through mutagenesis or trans-acting factor changes.

Main Methods:

  • Literature review of existing data on Pdr1 in Candida glabrata and related proteins in Saccharomyces cerevisiae.
  • Analysis of mechanisms regulating transcription factor activity.

Main Results:

  • Pdr1's function is restrained by multiple negative inputs.
  • Loss of these negative inputs can occur via protein mutagenesis or loss of trans-acting factors.

Conclusions:

  • While Pdr1 regulation is studied, the physiological reasons behind these regulatory mechanisms remain unclear.
  • Further research is needed to understand the underlying biological rationale for Pdr1 regulation in Candida glabrata.
Keywords:
Azole resistanceCandida glabrataPdr1Transcriptional regulation

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