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Related Experiment Video

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Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

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Black blood myocardial T₂ mapping.

Chengyan Wang^1,2, Jihye Jang^1,3, Ulf Neisius¹

¹Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

Magnetic Resonance in Medicine

|July 31, 2018

Summary

A new black blood imaging sequence, BEATS, improves myocardial T2 mapping by enhancing the blood-myocardium border definition. This cardiac MRI technique shows promise for clearer visualization in patients.

Keywords:

black blood double inversion recovery myocardial T2 mapping myocardial edema partial volume effect

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Published on: March 12, 2018

Area of Science:

Cardiovascular Magnetic Resonance Imaging
Biomedical Engineering
Medical Physics

Background:

Myocardial T2 mapping is crucial for assessing tissue characteristics.
Conventional bright-blood T2 mapping can be limited by blood pool artifacts.
Developing black blood techniques enhances image clarity and diagnostic potential.

Purpose of the Study:

To develop and evaluate a novel black blood, heart-rate adaptive T2-prepared balanced steady-state free-precession (BEATS) sequence for myocardial T2 mapping.
To assess the performance of the BEATS sequence in phantom and in vivo studies, including clinical cardiac MRI and animal models.

Main Methods:

The BEATS sequence utilizes preexcitation and double inversion recovery pulses for blood suppression.
Heart rate adaptation is achieved through auto-calculated timing and flip angles of the preexcitation pulse.
Image quality and artifacts were evaluated through numerical simulations, phantom studies, in vivo imaging in 36 patients and 1 swine, and reader assessments.

Main Results:

Phantom studies confirmed accurate T2 values across various heart rates.
Black blood myocardial T2 maps were successfully acquired in all subjects.
BEATS demonstrated sharper blood-myocardium border definition and reduced partial voluming compared to bright-blood T2 mapping, despite a slight decrease in precision and occasional residual blood artifacts.

Conclusions:

The BEATS sequence provides dark blood myocardial T2 maps with improved blood-myocardium border definition.
Further research is needed to establish the diagnostic accuracy of black blood T2 mapping using this novel sequence.