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Non-invasive 3D-Visualization with Sub-micron Resolution Using Synchrotron-X-ray-tomography
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Spatial correlation of native and engineered cartilage components at micron resolution.

James P Karchner1, William Querido1, Shital Kandel1

  • 1Department of Bioengineering, Temple University, Philadelphia, Pennsylvania.

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|July 31, 2018
PubMed
Summary

Fourier transform infrared imaging spectroscopy (FT-IRIS) visualizes extracellular matrix (ECM) and water distribution in engineered cartilage. This technique aids in understanding tissue composition for improved cartilage tissue engineering (TE).

Keywords:
FTIR imaging spectroscopyarticular cartilageengineered cartilageextracellular matrixmid-infrared spectroscopynear-infrared spectroscopy

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Spectroscopy

Background:

  • Articular cartilage defects are often treated with tissue engineering (TE).
  • Mechanical properties of engineered cartilage do not always correlate with extracellular matrix (ECM) production.
  • ECM distribution may influence mechanical outcomes in engineered cartilage.

Purpose of the Study:

  • To quantify and visualize the distribution of collagen, proteoglycan (PG), and water in native and engineered cartilage.
  • To assess the spatial correlation between ECM components and water content.
  • To evaluate the utility of Fourier transform infrared imaging spectroscopy (FT-IRIS) for cartilage TE.

Main Methods:

  • Fourier transform infrared imaging spectroscopy (FT-IRIS) was used to analyze native and engineered cartilage.
  • Samples were cryosectioned and analyzed in mid-infrared (MIR) and near-infrared (NIR) regions at 25 μm resolution.
  • Image processing was employed for colocalization analysis of matrix components and water.

Main Results:

  • Proteoglycan (PG) distribution strongly correlated with water content in both native and engineered cartilage.
  • NIR-derived matrix peaks showed significant correlation with MIR-derived collagen peaks, confirming collagen identification.
  • FT-IRIS enabled micron-level assessment of ECM and water spatial distribution.

Conclusions:

  • FT-IRIS is effective for visualizing and quantifying ECM and water distribution in cartilage.
  • The strong PG-water correlation highlights the role of PG in cartilage hydration.
  • This technique can guide the development of more effective cartilage tissue engineering strategies.