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Anti-inflammatory terpenoids from Cyperus rotundus rhizomes
Sabrin Ragab Mohamed-Ibrahim1, Gamal Abdallah Mohamed2, Maan Talaat Abdullah Khayat3
1Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia / Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Abstract:
Phytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D (1H and 13C), 2D (1H-1HCOSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC50s 0.22, 1.03, and 1.37 µM, respectively compared to indomethacin (IC50s 0.15, 0.69, and 0.81 μM, respectively). Moreover, 2 demonstrated significant activity with IC50s 0.57 (PGE2), 1.74 (COX-2) and 2.03 (LOX-5) μM.
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