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Testosterone, frailty and physical function in older men.

Benjumin Hsu1,2, Robert G Cumming1,3, David J Handelsman1

  • 1a ANZAC Research Institute , University of Sydney and Concord Hospital , Sydney , New South Wales , Australia.

Expert Review of Endocrinology & Metabolism
|July 31, 2018
PubMed
Summary
This summary is machine-generated.

Low testosterone levels may contribute to frailty in older men. Testosterone treatment shows modest gains in lean mass but has conflicting effects on muscle strength and minimal impact on physical function.

Keywords:
Frailtyageingandrogenmentestosterone

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Area of Science:

  • Gerontology
  • Endocrinology
  • Men's Health

Background:

  • Age-related decline in serum testosterone (T) is linked to frailty components like reduced energy, muscle strength, and physical function.
  • Frailty is a significant health concern in aging populations, impacting quality of life and healthcare costs.

Purpose of the Study:

  • To comprehensively review observational and interventional studies on the relationship between testosterone and frailty in older men.
  • To evaluate the effects of testosterone treatment on lean mass, muscle strength, and physical function in aging men.

Main Methods:

  • Systematic review of observational studies examining serum testosterone and dihydrotestosterone (DHT) in relation to frailty.
  • Analysis of interventional studies assessing testosterone therapy outcomes in frail and non-frail older men.

Main Results:

  • Testosterone treatment demonstrated modest improvements in lean mass for both frail and non-frail older men.
  • Evidence regarding the impact of testosterone on muscle strength remains conflicting.
  • The effect of testosterone treatment on physical function in older men was found to be weak.

Conclusions:

  • Testosterone therapy may offer limited benefits for frailty in older men, primarily through modest lean mass increases.
  • Further research is needed to clarify the role of testosterone in muscle strength and physical function in aging men.
  • Current evidence suggests a nuanced relationship between testosterone levels and frailty, requiring individualized treatment considerations.