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[In vitro differentiation of B lymphocytes]
In order to find if lymphoid colony-forming cells in the mouse are precursors of lymphocytes or are more differentitaed cells with a high proliferative capacity, their distribution between spleen and lymph node was compared to that of mitogen-sensitive B lymphocytes and that of precursurs of B lymphocytes assayed in mass cultures. The results and the responses to culture conditions suggest that these cell populations are different from each other.
In order to find if lymphoid colony-forming cells in the mouse are precursors of lymphocytes or are more differentitaed cells with a high proliferative capacity, their distribution between spleen and lymph node was compared to that of mitogen-sensitive B lymphocytes and that of precursurs of B lymphocytes assayed in mass cultures. The results and the responses to culture conditions suggest that these cell populations are different from each other.