Related Experiment Video
Updated: Feb 7, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Plasma Angiotensin-converting Enzyme Levels in Patients With Keloids and/or Hypertension
Jacob Stewart1, Donald A Glass 2nd2
1Department of Dermatology, UT Southwestern Medical Center, Dallas, TX.
Introduction:
Keloidal scarring is associated with hypertension and its pathogenesis remains poorly understood. The role of angiotensin-converting enzyme (ACE) in both hypertensive and fibrotic conditions suggests ACE may be a common mechanism for the pathogenesis of both hypertension and keloids.
Objective:
This paper aims to investigate the possible underlying role of ACE in keloid pathogenesis.
Materials And Methods:
Plasma samples were collected from participants with and without keloids. Enzyme-linked immunosorbent assays were then performed to determine ACE levels in the plasma samples. The plasma ACE levels of patients with and without keloid scarring were compared, while controlling for hypertension.
Results:
The 78 samples (39 keloid participants, 39 controls) were divided into 4 cohorts of either 18 (hypertensive) or 21 (normotensive) participants. The mean ± standard deviation ACE levels were 77.9 ± 31.2 ng/mL for the hypertensive keloid group (n = 18), 69.2 ± 18.8 ng/mL for the normotensive keloid group (n = 21), 72.7 ± 21.5 ng/mL for the hypertensive control group (n = 18), and 77.6 ± 18.5 ng/mL for the normotensive control group (n = 21). No significant differences in the mean plasma ACE levels were found between any of the 4 groups.
Conclusions:
Although the data showed no significant correlation between plasma ACE levels, keloids, and hypertension, additional studies may be pursued to determine the possible underlying role of ACE in keloid pathogenesis.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Enzymes
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
Enzyme Kinetics
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Hypertension I: Introduction
Hypertension II: Pathophysiology

