Related Experiment Video

Updated: Feb 7, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.7K

Early Predictors of Long-term Outcomes in Childhood Glaucoma

Ta C Chang1, Kara M Cavuoto, Alana L Grajewski

  • 1Bascom Palmer Eye Institute, Miami, FL.

Journal of Glaucoma
|July 31, 2018
PubMed

Insights

Early signs like nystagmus and failed angle surgery in childhood glaucoma predict poor visual outcomes. Failed angle surgery and media opacity also indicate poor intraocular pressure (IOP) control, informing a new staging system.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Glaucoma Research

Background:

  • Childhood glaucoma requires effective management strategies.
  • Predicting long-term outcomes is crucial for developing a data-based staging system.
  • Early-onset glaucoma presents unique challenges in visual acuity and intraocular pressure (IOP) control.

Purpose of the Study:

  • To identify early clinical factors associated with poor long-term visual acuity and IOP control in early-onset glaucoma.
  • To lay the groundwork for constructing a severity staging system for childhood glaucoma.

Main Methods:

  • Retrospective case series analysis of pediatric glaucoma patients.
  • Statistical modeling was used to analyze data from initial visits through final follow-up.
  • Early clinical characteristics were associated with final IOP control and visual acuity outcomes.

Main Results:

  • Nystagmus, anterior segment dysgenesis (ASD), and failed angle surgery by the third visit were associated with poorer final visual acuity.
  • Failed amblyopia therapy, failed angle surgery, nystagmus, media opacity (MO), or ASD at 3 years also predicted worse visual outcomes.
  • Failed angle surgery and MO were linked to uncontrolled IOP at the final visit.

Conclusions:

  • Early identification of nystagmus, ASD, or failed angle surgery can predict poor visual outcomes in infantile-onset glaucoma.
  • Failed angle surgery and MO are predictors of poor IOP control.
  • These findings are initial steps toward developing a childhood glaucoma severity staging system.
Abstract

More Related Videos

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

544
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.6K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.3K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K