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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
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[Acute Kidney Injury, AKI - Update 2018]
Daniel Patschan1, Gerhard Anton Müller2
1Innere Medizin I, Kardiologie, Angiologie und Nephrologie, Klinikum Brandenburg, Medizinische Hochschule Brandenburg.
Deutsche Medizinische Wochenschrift (1946)
|July 31, 2018
Summary
Acute Kidney Injury (AKI) is a common hospital complication. This article reviews preventing contrast-induced nephropathy, side effects of SGLT-2 inhibitors, and stem cell therapies for AKI.
Area of Science:
- Nephrology
- Internal Medicine
- Pharmacology
Background:
- Acute Kidney Injury (AKI) is a significant clinical challenge globally, particularly in hospitalized patients.
- Understanding AKI's multifactorial nature is crucial for effective management and prevention strategies.
Purpose of the Study:
- To review current evidence on preventing contrast-induced nephropathy (CIN).
- To examine the renal side effects associated with Sodium-Glucose co-Transporter-2 (SGLT-2) inhibitors.
- To explore the therapeutic potential of stem/progenitor cells in treating AKI.
Main Methods:
- Review of the PRESERVE trial comparing sodium chloride and sodium bicarbonate for CIN prevention.
- Analysis of studies on kidney-related adverse events of SGLT-2 inhibitors.
- Examination of research on stem/progenitor cell applications in AKI models and clinical trials.
Main Results:
- Findings from the PRESERVE trial regarding the efficacy of hydration strategies for CIN.
- Evidence detailing the spectrum of kidney-related side effects linked to SGLT-2 inhibitor use.
- Data on the regenerative and protective effects of various stem/progenitor cell types in AKI.
Conclusions:
- Optimal strategies for preventing contrast-induced nephropathy require further clarification.
- Careful monitoring for renal adverse events is necessary when prescribing SGLT-2 inhibitors.
- Stem/progenitor cell therapy holds promise as a future treatment modality for acute kidney injury.
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