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Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility

Marbod Weber1, Heidrun Steinle1, Sonia Golombek1

  • 1Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Tübingen, Germany.

Frontiers in Bioengineering and Biotechnology
|August 1, 2018
PubMed

Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO 10993-4 are required prior to clinical applications. In this review, we summarize essential aspects regarding the evaluation of the hemocompatibility of biomaterials and the required in vitro analyses for determining the blood compatibility. Static, agitated, or shear flow models are used to perform hemocompatibility studies. Before and after the incubation of the test material with fresh human blood, hemolysis, cell counts, and the activation of platelets, leukocytes, coagulation and complement system are analyzed. Furthermore, the surface of biomaterials are evaluated concerning attachment of blood cells, adsorption of proteins, and generation of thrombus and fibrin networks.

Keywords:
biomaterialsblood contactcoagulationcomplement systemhemocompatibility

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