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Virological aspects on herpesvirus infections
Scandinavian Journal of Infectious Diseases. Supplementum
|January 1, 1985
Summary
The human herpesviridae family includes five key viruses: herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and cytomegalovirus (CMV). These DNA viruses replicate in cell nuclei and can establish lifelong latent infections, though latency conditions differ among them.
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Background:
- The family Herpesviridae comprises significant human pathogens.
- These viruses are classified into three subfamilies based on phenotypic properties.
- Key human herpesviruses include HSV-1, HSV-2, VZV, and CMV.
Purpose of the Study:
- To provide an overview of the Herpesviridae family.
- To highlight the characteristics of major human herpesvirus pathogens.
- To discuss viral replication, structure, and latency.
Main Methods:
- Review of existing literature on Herpesviridae.
- Analysis of viral genomic and structural features.
- Comparison of replication cycles and latency mechanisms.
Main Results:
- Herpesviridae possess DNA genomes and replicate within eukaryotic cell nuclei.
- Virions consist of enveloped icosahedral nucleocapsids.
- All herpesviruses can establish latent infections, with varying conditions.
Conclusions:
- Herpesviridae are a diverse group of DNA viruses with significant impact on human health.
- Understanding their structure and replication is crucial for disease management.
- Latency is a hallmark of herpesvirus infections, presenting unique challenges.