Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Applications of Integration to Find Blood Flow01:27

Applications of Integration to Find Blood Flow

56
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
56
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

758
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
758
Dehydration Synthesis01:15

Dehydration Synthesis

149.9K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
149.9K
Overview of Microsoft Excel as a Data Analysis Tool01:13

Overview of Microsoft Excel as a Data Analysis Tool

1.6K
Microsoft Excel is a cornerstone tool for data analysis and statistical operations, offering a wide array of functionalities to manage, analyze, and visualize data efficiently. Recognized for its versatility, Excel facilitates the performance of basic to complex statistical operations, serving as an indispensable asset for analysts, researchers, and students alike. Excel's significance in data analysis emanates from its spreadsheet environment, where data can be organized in rows and...
1.6K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

61.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.4K
Performing a Simple Data Analysis using MS-Excel Function01:17

Performing a Simple Data Analysis using MS-Excel Function

1.1K
Microsoft Excel offers a suite of functions and tools ideal for statistical analysis, making it accessible to students and researchers. This article outlines fundamental Excel functions pivotal for data analysis.
SUM: This function calculates the total sum of a range of values. It's the foundation for aggregating data, essential for determining overall trends and totals in datasets.
AVERAGE: It computes the mean value of a given set of numbers, providing a quick insight into the central...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerated preparation of pyridazines enabled by high-temperature diazo cycloadditions in continuous flow mode.

Chemical communications (Cambridge, England)·2026
Same author

Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities.

Organic process research & development·2026
Same author

The Impact of Continuous Flow Technology and Collaboration between Academia and Industry.

JACS Au·2026
Same author

Photocatalytic Addition of <i>N</i>-Oxazolidinone Radicals to Arenes and Heteroarenes in Batch and in Flow Mode.

Organic letters·2025
Same author

Photochemical Synthesis of Ynones from Aryl Aldehydes and Sulfone-Based Alkynes.

The Journal of organic chemistry·2025
Same author

Photochemical Flow Synthesis of Trisubstituted Oxazoles Enabled by High-Power UV-B LED Modules.

Organic letters·2025

Related Experiment Video

Updated: Feb 7, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K

Integrating continuous flow synthesis with in-line analysis and data generation.

Marcus Baumann1

  • 1School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland. marcus.baumann@ucd.ie.

Organic & Biomolecular Chemistry
|August 1, 2018
PubMed
Summary
This summary is machine-generated.

Continuous flow synthesis is advancing beyond batch processing, requiring integration with in-line analysis and purification. This enables efficient multi-step reactions and simultaneous bioactivity data generation for fine chemicals.

More Related Videos

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.2K
Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
07:06

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

12.1K

Related Experiment Videos

Last Updated: Feb 7, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K
Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.2K
Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
07:06

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

12.1K

Area of Science:

  • Chemical Synthesis
  • Process Chemistry
  • Analytical Chemistry

Background:

  • Continuous flow synthesis has evolved from an academic concept to a significant industrial technology.
  • The advantages of flow chemistry over traditional batch processing are well-established, driving wider adoption.
  • Current advancements necessitate integrating flow synthesis into a cohesive synthesis concept, moving beyond its role as a standalone technology.

Purpose of the Study:

  • To review the current state of integrated continuous flow synthesis.
  • To identify challenges and opportunities in combining flow synthesis with in-line analysis and purification.
  • To highlight the potential for telescoped multi-step sequences and concurrent bioactivity assessment.

Main Methods:

  • Review of current literature and state-of-the-art techniques in continuous flow synthesis.
  • Analysis of integrated systems incorporating in-line analytical and purification modules.
  • Discussion of strategies for multi-step reaction telescoping and real-time data generation.

Main Results:

  • Continuous flow synthesis is transitioning towards integrated platforms.
  • In-line analysis and purification are crucial for efficient multi-step sequences.
  • Concurrent generation of bioactivity data alongside synthesis is becoming feasible.

Conclusions:

  • Integrating continuous flow synthesis with in-line technologies is essential for future advancements.
  • This integration facilitates efficient, telescoped synthesis and rapid compound evaluation.
  • Embracing these integrated approaches presents significant opportunities for fine chemical development.