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Retrospective analysis of rhabdomyosarcoma (RMS) in children in a single center

Meng Li1, Xiuju Bian1,2, Rui Jing1,3

  • 1Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.

Thoracic Cancer
|August 1, 2018
PubMed

Insights

This study found that a refined therapeutic protocol significantly improved outcomes for children with rhabdomyosarcoma (RMS). Positive treatment, especially combined therapy, led to better efficacy and prognosis in pediatric RMS patients.

Area of Science:

  • Pediatric Oncology
  • Cancer Therapeutics

Background:

  • Rhabdomyosarcoma (RMS) is a significant pediatric cancer.
  • Understanding the impact of clinical features and treatment protocols is crucial for improving outcomes.

Purpose of the Study:

  • To evaluate the influence of clinical features and a refined therapeutic protocol on rhabdomyosarcoma (RMS) treatment efficacy and prognosis in children.
  • To assess the impact of a specific refined protocol (version 2009.9.1) on pediatric RMS patients.

Main Methods:

  • Retrospective analysis of 40 children diagnosed with RMS.
  • Application of a refined therapeutic protocol (Shanghai Children's Medical Center, version 2009.9.1).
  • Analysis of demographic, clinical, pathological, efficacy, and prognosis data.

Main Results:

  • Among 23 treated patients, risk stratification showed 2 low, 12 medium, and 9 high-risk cases.
  • Low and medium-risk groups demonstrated better prognoses than the high-risk group.
  • Treated patients exhibited higher survival rates and longer survival durations compared to untreated patients.

Conclusions:

  • Positive and combined treatment approaches are recommended for children with RMS.
  • The refined therapeutic protocol shows enhanced efficacy and a significant positive impact on long-term prognosis for pediatric rhabdomyosarcoma.
Abstract

Keywords:
Childrenprognosisrhabdomyosarcomatherapeutic efficacy

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